01 Effortless comic chemistry opposite Hugh Grant.
Drew Barrymore – 10 Best Movies
By Vlad Zakh · September 29, 2025
Scream’s opening scene remains one of the most famous cold opens in horror history, and 50 First Dates, years later, showed the warmer romantic-comedy register she’d built her career on since.
01 
02 An ensemble rom-com she anchors with real warmth.
03 A more dramatic register than most of her romantic-comedy work.
04 A small but pivotal supporting role in a genuinely strange cult classic.
05 A high-school-undercover premise she carries on pure charm.
06 Also produced the film, part of her broader Hollywood second act.
07 Easy, natural chemistry with Adam Sandler that led to a whole run of films together.
08 Her breakout role, still one of the most beloved child performances made.
09 A high-concept rom-com premise she makes feel genuinely sweet.
10 One of the most famous cold opens in horror history, and she's the reason it works.
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